If you do not live near small businesses, consider online places like Etsy.com. Many artisans on etsy are able to create amazing items that would make awesome and one-of-a-kind gifts for friends and family.
Example: I was thinking about the upcoming cold weather (I have random thoughts all the time). I was trying to figure out if I needed to think about buying a new pair of gloves that allow me to wear my wedding band and engagement ring without it getting stuck to the weave. Then I started to think about an alternate ring that I could wear that didn't stick up like my engagement ring.
I ended up wanting a ring made with my husband's signature. His signature is certainly "special" and I even cringe when he signs his name because I do teach cursive. I went to etsy and searched for "signature rings" which yielded many affordable results. I ended up going with a store called SilverHandwriting and all I had to do was have my husband write his name, take a photo of it with my phone and upload it to etsy. Then when the shop owner said she could do it, I spent a mere $30ish and a week later I have an awesome ring!
It went from this:
Now I want signature jewelry for everything! :)